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Technology
Based On Chemical Substances
Today,
most manufacturers of beauty and medicinal products for topical application
claim that their products are based on natural active ingredients and,
therefore, have
biological activity. In reality, these products have low biological activity
since they contain waxes, mineral oils, ionic chemical surfactants,
preservatives, thickeners, polymeric gel-(or emulsion) formation and other
polymeric materials. These
materials actually block pores on the skin and block active centers of natural
active ingredients, thereby significantly lowering the effectiveness of the
natural active ingredients in the products. Why
do companies do
this? The reasons are: (i) chemical substances are inexpensive and (ii)
technology of manufacturing these products is simple (H.E. Junginger “Multiphase Emulsion in Surfactants in Cosmetics, Vol.68, Marcel Dekker,
1997). However,
many chemical substances cause adverse side effects. Furthermore,
the technology used to manufacture these chemical substances is
inexpensive and can be realized easily
because it does not require strong control of thermodynamic parameters to
produce stable products.
Technology Based On Natural Substances
To increase biological activities, the natural products manufactured by
Iren Corporation. have complex structural elements of colloidal dimensions that
form a three-dimensional network within the system. They are responsible for the
products’ dermatological properties such as feel, spread ability, penetration
through skin, cooling/warming effects, and their possible interactions with skin
lipids. This formation during the manufacturing process requires special control
of temperature, mixing speed, and shear rates. Iren Corporation. has developed a
new technology which allows us to produce water-soluble
products in form of a triple emulsion/suspension system.
The triple emulsion
(i.e. Water-1/Oil/Water-2
or W-1/O/W-2
emulsion)
is the aqueous dispersed phase (Water -1
or W-1) with oil (Oil
or O) globules in which the water globules
(Water-2 or W-2)
are dispersed (as shown on next page). The solid part of the natural products consists
of fine particles (size less 0.1 micron) of microencapsulated sulfur, zinc oxide, etc.
All
natural products are based on the natural substances (such as natural non-ionic
surfactants, natural preservatives, natural thickeners, natural unsaturated
oils, and etc.) that have been manufactured using our new US Patented
technology. The stable water-soluble triple emulsion/suspension system using
this technology can be made in 4-steps. Each technological step of a process for
production stable triple emulsion/suspension (shelf-life of 3 or more years) can
be realized only for
a narrow range of thermodynamic parameters
(such as active
ingredients’ and surfactants’ concentrations, temperature, shear rate of
homogenization and rate of temperature reduction, and etc.). Therefore,
manufacturing of the product requires accurate control of all thermodynamic
parameters during the whole process.
Specific
our Technology
Modern science has rediscovered many
natural ingredients (known for ages by our ancestry), which have advanced the
medical arts and offered more healing possibilities. However, the technology of
administration (oral ingestion) remained mostly the same till now. One well
established, yet incompletely developed delivery mode has been topical creams
and lotions, primarily utilized in cosmetic applications. The great barrier to
wider application of such a pathway has been the structure of the skin itself,
which has proven impermeable to a wide range of compounds, most notably the
class of molecules know as "water soluble". This limitation has so strongly
influenced perception of range restriction of compound delivery across the skin.
But now, through the research of NU Technology, this
border has been unlocked and opened to transdermal traffic of virtually all
biological active compounds. But just how is this
accomplished? The mechanics of NU Technology’s invention allows to create a
triple emulsion that creates an unusually stable matrix into which nutrient
compounds can be fed. The emulsion was named "Liquid Crystal". This refers to
the creation, through the "microencapsulation" of molecules of the active
ingredients in the emulsion, of actual liquid crystals in a state of stable
suspension. This special physical configuration has the effect of making large
molecules behave, in relation to the skin barrier, as though they are "smaller",
and allowed to cross what would otherwise prevent penetration. Sort of a
chemical version of having a friend who is a member of an exclusive club getting
you, a non-member, admitted to its premises.
But what is the
significance in terms of the medical value of such invention? An important
aspect of this technology is the efficiency factor. Active ingredients can
target the problem areas directly instead of going through digestive system, as
oral medication, loosing more than 75% of its strength in the process. In other
words, "Liquid Crystal" allows for great reduction in dose levels of any given
substance compared to oral titration. Reduction of excess compounds of any kind,
even biologically "benign" compounds, is always the soundest medical approach,
and becomes imperative when any substances that a person may have sensitivity to
is being administered. For people experiencing the excruciating pain, the amount
of time it takes for the medicine to start working is also an important factor.
This amount of time is shorten by topical administration, since the medicine is
applied right to the problem area instead of going through the whole body.
Another advantage of "Liquid Crystal" emulsion is its flexibility. For instance,
many medicines must be taken on an empty stomach, due to foodstuffs in the
stomach interfering with uptake. Another scenario is that of people who
experience side effects ingesting certain compounds, among them vitamin C,
highly beneficial in many ways.
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